ANCHR

Abscission/NoCut checkpoint regulator;Isoform 3 of Abscission/NoCut checkpoint regulator

Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission.

Matrix Type

  • Tissue/Cells

Gene Symbol

  • ZFYVE19

UniProt ID

  • Q96K21
  • Q96K21-3

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