AMPL

Cytosol aminopeptidase; Isoform 2 of Cytosol aminopeptidase;Cytosol aminopeptidase

Cytosolic metallopeptidase that catalyzes the removal of unsubstituted N-terminal hydrophobic amino acids from various peptides. The presence of Zn(2+) ions is essential for the peptidase activity, and the association with other cofactors can modulate the substrate spectificity of the enzyme. For instance, in the presence of Mn(2+), it displays a specific Cys-Gly hydrolyzing activity of Cys-Gly-S-conjugates. Involved in the metabolism of glutathione and in the degradation of glutathione S-conjugates, which may play a role in the control of the cell redox status.

Matrix Type

  • Plasma
  • Tissue/Cells

Gene Symbol

  • LAP3

UniProt ID

  • P28838

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