AMOL2

Isoform 3 of Angiomotin-like protein 2; Isoform 2 of Angiomotin-like protein 2; Isoform 4 of Angiomotin-like protein 2;Angiomotin-like protein 2

Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC.

Matrix Type

  • Tissue/Cells

Gene Symbol

  • AMOTL2

UniProt ID

  • Q9Y2J4
  • Q9Y2J4-3
  • Q9Y2J4-4

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