3BP5

SH3 domain-binding protein 5; Isoform 2 of SH3 domain-binding protein 5

Functions as a guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25 (PubMed:26506309, PubMed:30217979). Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death.

Associated with:

Matrix Type

  • Tissue/Cells

Gene Symbol

  • SH3BP5

UniProt ID

  • O60239

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