Publications by Sapient and our collaborators

Find an up-to-date listing of multi-omics biomarker publications authored by Sapient’s team members and our partners.

biomarker discovery services partner

Rapid Liquid Chromatography-Mass Spectrometry (rLC-MS) for Deep Metabolomics Analysis of Population Scale Studies

Watrous J., Tiwari S., et al.

Additional Sapient authors include Tao Long, Adam Large, Kim Lagerborg, Kate Gallagher, Khoi Dao, Sejun Park, D’Angelo Aguirre, Cameron Lamoureux, Jamie Cho, Roland Nilsson, Jonathan Usuka, and Mohit Jain

Maternal Metabolomic Signatures of Spontaneous Preterm Birth in Bangladesh: Evidence from the AMANHI Bangladesh Cohort

Akhter K., et al. medRxiv (2025). doi: 10.1101/2025.08.07.25333197

Sapient provided rLC-MS based metabolomics analysis, global compound identification, and statistical analysis support; Sapient team members Kim Lagerborg, Tao Long, and Cameron Lamoureux were also contributing authors

Protocol: the International Milk Composition (IMiC) Consortium - a harmonized secondary analysis of human milk from four studies

Feher K., et al. Frontiers in Nutrition (2025). doi: 10.3389/fnut.2025.1548739

Describes how Sapient will provide exploratory analysis of metabolites with known and unknown identities as part of the comprehensive harmonized analysis of human milk from low, middle and high-resource settings to inform novel strategies for supporting maternal-child nutrition and health.

Isotope tracing-based metabolite identification for mass spectrometry metabolomics

Secilmisa D., et al. bioRxiv (2025). doi: 10.1101/2025.04.07.647691

Sapient provided analytical chemistry support for validation experiments; Sapient team members Roland Nilsson, Jeramie Watrous, and Mo Jain were also contributing authors

Plasma Lipid Metabolites, Clinical Glycemic Predictors, and Incident Type 2 Diabetes

Arjana Begzati, et al. Diabetes Care (2025). doi: 10.2337/dc24-2266

Sapient provided nontargeted metabolomics data and analyses; Sapient team members Tao Long, Jeramie Watrous, and Mo Jain were also contributing authors

Lysosomal dysfunction and inflammatory sterol metabolism in pulmonary arterial hypertension

Lloyd D. Harvey, et al. Science (2025). doi: 10.1126/science.adn7277

Sapient provided discovery metabolomics data and analyses; Sapient team member Mo Jain was also a contributing author

Global 13C tracing and metabolic flux analysis of intact human liver tissue ex vivo

Grankvist, N., Jönsson, C., Hedin, K., et al. Nat Metab (2024). doi: 10.1038/s42255-024-01119-3

Authored by Sapient scientists and collaborators, with Sapient contributing nontargeted mass spectrometry data

Reconstructing the landscape of gut microbial species across 29,000 diverse individuals

Segota I, Watrous D, Kantz E, Nallamshetty S, Tiwari S, Cheng S, Jain M, Long T. Nucleic Acids Research. (2023). doi: 10.1093/nar/gkad249
Contributed to by members of the Sapient team

A Multi-Omics and Human Biomonitoring Approach to Assessing the Effectiveness of Fortified Balanced Energy–Protein Supplementation on Maternal and Newborn Health in Burkina Faso: A Study Protocol

Bastos-Moreira Y, Ouédraogo L, et al. Nutrients. (2023). doi: 10.3390/nu15184056

Featuring Sapient’s nontargeted metabolomics method as part of the multi-omics study protocol

Association between fetal abdominal growth trajectories, maternal metabolite signatures early in pregnancy, and childhood growth and adiposity: prospective observational multinational INTERBIO-21st fetal study

Villar J, Ochieng R, Gunier RB, et al. Lancet Diabetes & Endocrinology (2022), doi: 10.1016/S2213-8587(22)00215-7.

Featuring Sapient’s work with University of Oxford

Awareness of SARS-CoV-2 Omicron Variant Infection Among Adults With Recent COVID-19 Seropositivity

Joung SY, Ebinger JE, Sun N, et al. JAMA Network Open (2022), doi:10.1001/jamanetworkopen.2022.27241

Featuring our work with Cedars-Sinai

Deep Neural Networks for Classification of LC-MS Spectral Peaks

Kantz E, Tiwari S, Watrous J, Cheng S, Jain M. Analytical Chemistry (2019), doi: 10.1021/acs.analchem.9b02983
Contributed to by members of the Sapient team
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