Proving Target Relevancy: A Fast Path to Functional Biology with FFPE Proteomics

Why is functional proteomics analysis so important for advancing cancer therapeutics?

The majority of oncology therapies in development today are precision-guided, yet late-stage clinical failures remain common – largely stemming from insufficient human evidence to confirm an intended target is truly relevant in patients. To date, genomics measures provide limited insight into biology relevance, and to resolve this uncertainty and derisk development, teams need proof of mechanism: direct demonstration that the target is active and biologically consequential in the intended patient population.

In this webinar, Sapient will share how next-generation FFPE proteomics can interrogate target relevancy through deep, direct measure of functional biology in FFPE tissue – leveraging the largest archives of outcomes-linked oncology samples to fast-track delivery of actionable human evidence. You will learn:

• How functional proteomics analysis enables direct measure of protein expression, pathway activity, immune biology, and resistance mechanisms, bridging the gap between genomic target discovery and functional target validation
• The value of profiling proteins, the ultimate effectors of disease states, to explain disease heterogeneity and pathway relevance beyond what is inferred by transcriptomics
• Practical ways to fast-track the generation of mechanistic insights without new trials or collections by leveraging the vast repositories of existing, archived FFPE samples