NT2NB;NT2NA;NT2NC;NT2NR

Isoform 2 of Notch homolog 2 N-terminal-like protein B; Isoform 2 of Notch homolog 2 N-terminal-like protein C; Notch homolog 2 N-terminal-like protein A; Notch homolog 2 N-terminal-like protein C;Notch homolog 2 N-terminal-like protein R; Isoform 3 of Notch homolog 2 N-terminal-like protein A; Notch homolog 2 N-terminal-like protein B

Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway (PubMed:29561261, PubMed:29856954, PubMed:29856955). Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production (PubMed:29856954, PubMed:29856955). Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect (PubMed:29856954, PubMed:29856955). Enhances Notch signaling pathway in a non-cell-autonomous manner via direct interaction with NOTCH2 (PubMed:29856954). Also promotes Notch signaling pathway in a cell-autonomous manner through inhibition of cis DLL1-NOTCH2 interactions, which promotes neuronal differentiation (PubMed:29856955).

Associated with:

Matrix Type

  • Tissue/Cells

Gene Symbol

  • NOTCH2NLB

UniProt ID

  • A0A096LNW5
  • P0DPK3-2
  • P0DPK4
  • P0DPK4-2
  • Q7Z3S9
  • Q7Z3S9-3

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