MOB1A;MOB1B

Isoform 2 of MOB kinase activator 1B;MOB kinase activator 1B; MOB kinase activator 1A;MOB kinase activator 1B; MOB kinase activator 1A

Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L.

    Matrix Type

    • Plasma
    • Tissue/Cells

    Gene Symbol

    • MOB1B

    UniProt ID

    • Q7L9L4
    • Q9H8S9

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