VPS54

Vacuolar protein sorting-associated protein 54; Isoform 4 of Vacuolar protein sorting-associated protein 54; Isoform 5 of Vacuolar protein sorting-associated protein 54; Isoform 2 of Vacuolar protein sorting-associated protein 54; Isoform 3 of Vacuolar protein sorting-associated protein 54

Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD (PubMed:18367545). Within the GARP complex, required to tether the complex to the TGN. Not involved in endocytic recycling (PubMed:25799061).

Matrix Type

Tissue/Cells

Gene Symbol

VPS54

UniProt ID

Q9P1Q0
Q9P1Q0-3
Q9P1Q0-4
Q9P1Q0-5

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VPS54

Vacuolar protein sorting-associated protein 54; Isoform 4 of Vacuolar protein sorting-associated protein 54; Isoform 5 of Vacuolar protein sorting-associated protein 54; Isoform 2 of Vacuolar protein sorting-associated protein 54; Isoform 3 of Vacuolar protein sorting-associated protein 54

Matrix Type

Gene Symbol

UniProt ID

Request the VPS54 Assay

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