VP13B

Isoform 6 of Intermembrane lipid transfer protein VPS13B; Isoform 2 of Intermembrane lipid transfer protein VPS13B;Intermembrane lipid transfer protein VPS13B

Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Binds phosphatidylinositol 3-phosphate (By similarity). Functions as a tethering factor in the slow endocytic recycling pathway, to assist traffic between early and recycling endosomes (PubMed:24334764, PubMed:30962439, PubMed:32375900). Involved in the transport of proacrosomal vesicles to the nuclear dense lamina (NDL) during spermatid development (By similarity). Plays a role in the assembly of the Golgi apparatus, possibly by mediating trafficking to the Golgi membrane (PubMed:21865173). Plays a role in the development of the nervous system, and may be required for neuron projection development (PubMed:25492866, PubMed:32560273). May also play a role during adipose tissue development (PubMed:26358774). Required for maintenance of the ocular lens (By similarity).

Matrix Type

  • Tissue/Cells

Gene Symbol

  • VPS13B

UniProt ID

  • Q7Z7G8
  • Q7Z7G8-6

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