TYW1

S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1

Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3′-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis (By similarity).

    Matrix Type

    • Tissue/Cells

    Gene Symbol

    • TYW1

    UniProt ID

    • Q9NV66

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