TSSC4

Isoform 2 of U5 small nuclear ribonucleoprotein TSSC4;U5 small nuclear ribonucleoprotein TSSC4

Protein associated with the U5 snRNP, during its maturation and its post-splicing recycling and which is required for spliceosomal tri-snRNP complex assembly in the nucleus (PubMed:34131137, PubMed:35188580). Has a molecular sequestering activity and transiently hinders SNRNP200 binding sites for constitutive splicing factors that intervene later during the assembly of the spliceosome and splicing (PubMed:35188580). Together with its molecular sequestering activity, may also function as a molecular adapter and placeholder, coordinating the assembly of the U5 snRNP and its association with the U4/U6 di-snRNP (PubMed:34131137).

Matrix Type

  • Tissue/Cells

Gene Symbol

  • TSSC4

UniProt ID

  • Q9Y5U2

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