TLK2

Isoform 2 of Serine/threonine-protein kinase tousled-like 2;Serine/threonine-protein kinase tousled-like 2

Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation (PubMed:10523312, PubMed:11470414, PubMed:12660173, PubMed:12955071, PubMed:29955062, PubMed:33323470, PubMed:9427565). Phosphorylates the chromatin assembly factors ASF1A and ASF1B (PubMed:11470414, PubMed:20016786, PubMed:29955062, PubMed:35136069). Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly (PubMed:20016786). Negative regulator of amino acid starvation-induced autophagy (PubMed:22354037).

Associated with:

Matrix Type

  • Plasma
  • Tissue/Cells

Gene Symbol

  • TLK2

UniProt ID

  • Q86UE8

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