May constitute a control point in macrophage inflammatory response, promoting LPS-induced TLR4-mediated TNF production (PubMed:20644716). Determines the threshold for activation of B cells by low-affinity and low-avidity ligands via PLCG2 activation and its downstream pathways (By similarity).

Matrix Type

  • Plasma
  • Tissue/Cells

Gene Symbol

  • THEMIS2

UniProt ID

  • Q5TEJ8

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