As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (By similarity). Behaves as a kinesin cargo, providing a functional binding site for kinesin-1 at the nuclear envelope. Hence may contribute to the establishment of secretory epithelial morphology by promoting kinesin-dependent apical migration of the centrosome and Golgi apparatus and basal localization of the nucleus (By similarity).

    Matrix Type

    • Tissue/Cells

    Gene Symbol

    • SYNE4

    UniProt ID

    • Q8N205

    Request the SYNE4 Assay

    Tell us a little more about your study so we can optimize the assay for your specific needs.

    "*" indicates required fields

    This field is for validation purposes and should be left unchanged.