Plays a role in DNA double-strand break (DBS) repair via homologous recombination (HR). Serves as a scaffolding protein that helps to promote the recruitment of DNA-processing enzymes like the helicase BLM and recombinase RAD51 to site of DNA damage, and hence contributes to maintain genomic integrity.

Associated with:

Matrix Type

  • Tissue/Cells

Gene Symbol

  • SPIDR

UniProt ID

  • Q14159

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