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JIP4

C-Jun-amino-terminal kinase-interacting protein 4;Isoform 4 of C-Jun-amino-terminal kinase-interacting protein 4;Isoform 5 of C-Jun-amino-terminal kinase-interacting protein 4

The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity).

    Matrix Type

    • Plasma
    • Tissue/Cells

    Gene Symbol

    • SPAG9

    UniProt ID

    • O60271
    • O60271-4
    • O60271-5
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