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SETD6

Isoform 2 of N-lysine methyltransferase SETD6;N-lysine methyltransferase SETD6

Protein-lysine N-methyltransferase. Monomethylates ‘Lys-310’ of the RELA subunit of NF-kappa-B complex, leading to down-regulation of NF-kappa-B transcription factor activity (PubMed:21131967, PubMed:21515635, PubMed:30189201). Monomethylates ‘Lys-8’ of H2AZ (H2AZK8me1) (PubMed:23324626). Required for the maintenance of embryonic stem cell self-renewal (By similarity). Methylates PAK4.

    Matrix Type

    • Tissue/Cells

    Gene Symbol

    • SETD6

    UniProt ID

    • Q8TBK2
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