RPGF1

Rap guanine nucleotide exchange factor 1; Isoform 3 of Rap guanine nucleotide exchange factor 1; Isoform 4 of Rap guanine nucleotide exchange factor 1; Isoform Short of Rap guanine nucleotide exchange factor 1

Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1 (PubMed:12432078). Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth.

Matrix Type

  • Tissue/Cells

Gene Symbol

  • RAPGEF1

UniProt ID

  • Q13905
  • Q13905-3
  • Q13905-4

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