PTPRC

Receptor-type tyrosine-protein phosphatase C; Isoform 8 of Receptor-type tyrosine-protein phosphatase C;Receptor-type tyrosine-protein phosphatase C; Isoform 5 of Receptor-type tyrosine-protein phosphatase C; Isoform 2 of Receptor-type tyrosine-protein phosphatase C; Isoform 6 of Receptor-type tyrosine-protein phosphatase C; Isoform 7 of Receptor-type tyrosine-protein phosphatase C; Isoform 4 of Receptor-type tyrosine-protein phosphatase C; Isoform 3 of Receptor-type tyrosine-protein phosphatase C

Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor (PubMed:35767951). Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity). ; (Microbial infection) Acts as a receptor for human cytomegalovirus protein UL11 and mediates binding of UL11 to T-cells, leading to reduced induction of tyrosine phosphorylation of multiple signaling proteins upon T-cell receptor stimulation and impaired T-cell proliferation.

Matrix Type

  • Plasma
  • Tissue/Cells

Gene Symbol

  • PTPRC

UniProt ID

  • P08575
  • P08575-4
  • P08575-5
  • P08575-6
  • P08575-7
  • P08575-8
  • P08575-9

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