2ABD

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and may also direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity).

Associated with:

Matrix Type

  • Tissue/Cells

Gene Symbol

  • PPP2R2D

UniProt ID

  • Q66LE6

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