DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3′-5′ proofreading exonuclease activity. Forms a Schiff base with 5′-deoxyribose phosphate at abasic sites, but does not have lyase activity.

Associated with:

Matrix Type

  • Tissue/Cells

Gene Symbol

  • POLK

UniProt ID

  • Q9UBT6

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