PF21A

Isoform 3 of PHD finger protein 21A;Isoform 2 of PHD finger protein 21A;PHD finger protein 21A; Isoform 2 of PHD finger protein 21A; Isoform 3 of PHD finger protein 21A

Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of ‘Lys-4’ of histone H3 in vitro, suggesting a role in demethylation regulation.

    Matrix Type

    • Tissue/Cells

    Gene Symbol

    • PHF21A

    UniProt ID

    • Q96BD5
    • Q96BD5-2
    • Q96BD5-3

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