PHC2

Isoform 2 of Polyhomeotic-like protein 2; Isoform 5 of Polyhomeotic-like protein 2; Isoform 4 of Polyhomeotic-like protein 2;Polyhomeotic-like protein 2

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A ‘Lys-119’, rendering chromatin heritably changed in its expressibility.

    Matrix Type

    • Tissue/Cells

    Gene Symbol

    • PHC2

    UniProt ID

    • Q8IXK0
    • Q8IXK0-4
    • Q8IXK0-5

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