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PDE5A

cGMP-specific 3',5'-cyclic phosphodiesterase; Isoform PDE5A2 of cGMP-specific 3',5'-cyclic phosphodiesterase;cGMP-specific 3',5'-cyclic phosphodiesterase

Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5′-GMP (PubMed:15489334, PubMed:9714779). Specifically regulates nitric-oxide-generated cGMP (PubMed:15489334).

Associated with:

Matrix Type

  • Plasma
  • Tissue/Cells

Gene Symbol

  • PDE5A

UniProt ID

  • O76074
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