NUDT7

Isoform 3 of Peroxisomal coenzyme A diphosphatase NUDT7;Peroxisomal coenzyme A diphosphatase NUDT7; Isoform 2 of Peroxisomal coenzyme A diphosphatase NUDT7

Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4′-phosphopantetheine and adenosine 3′,5′-bisphosphate (By similarity). Cleaves CoA, CoA esters and oxidized CoA with similar efficiencies (By similarity). Preferentially hydrolyzes medium-chain acyl-CoAs and bile acid-CoAs (By similarity). Has no activity toward NDP-sugars, CDP-alcohols, (deoxy)nucleoside 5′-triphosphates, nucleoside 5′-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5′-monophospho-p-nitrophenyl ester (By similarity). May be required to eliminate oxidized CoA from peroxisomes, or regulate CoA and acyl-CoA levels in this organelle in response to metabolic demand (By similarity). Does not play a role in U8 snoRNA decapping activity (By similarity). Binds U8 snoRNA (By similarity). Exhibits decapping activity towards dpCoA-capped RNAs in vitro (By similarity).

    Matrix Type

    • Tissue/Cells

    Gene Symbol

    • NUDT7

    UniProt ID

    • P0C024
    • P0C024-3

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