Required for normal ciliary development and function. Inhibits disheveled-1-induced canonical Wnt-signaling activity and may also play a role in the control of non-canonical Wnt signaling which regulates planar cell polarity. Probably acts as a molecular switch between different Wnt signaling pathways. Required for proper convergent extension cell movements.

Matrix Type

  • Tissue/Cells

Gene Symbol

  • NPHP3

UniProt ID

  • Q7Z494

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