KBRS2

Isoform 2 of NF-kappa-B inhibitor-interacting Ras-like protein 2;NF-kappa-B inhibitor-interacting Ras-like protein 2

Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity).

Matrix Type

  • Tissue/Cells

Gene Symbol

  • NKIRAS2

UniProt ID

  • Q9NYR9

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