MTA3

Isoform 2 of Metastasis-associated protein MTA3;Metastasis-associated protein MTA3

Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:12705869, PubMed:16428440, PubMed:28977666). Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels (PubMed:12705869). Contributes to transcriptional repression by BCL6 (PubMed:15454082).

    Matrix Type

    • Tissue/Cells

    Gene Symbol

    • MTA3

    UniProt ID

    • Q9BTC8

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