MCF2L

Isoform 9 of Guanine nucleotide exchange factor DBS; Isoform 2 of Guanine nucleotide exchange factor DBS; Isoform 8 of Guanine nucleotide exchange factor DBS; Isoform 6 of Guanine nucleotide exchange factor DBS; Isoform 4 of Guanine nucleotide exchange factor DBS; Isoform 7 of Guanine nucleotide exchange factor DBS;Guanine nucleotide exchange factor DBS; Isoform 3 of Guanine nucleotide exchange factor DBS; Isoform 5 of Guanine nucleotide exchange factor DBS

Guanine nucleotide exchange factor that catalyzes guanine nucleotide exchange on RHOA and CDC42, and thereby contributes to the regulation of RHOA and CDC42 signaling pathways (By similarity). Seems to lack activity with RAC1. Becomes activated and highly tumorigenic by truncation of the N-terminus (By similarity). Isoform 5 activates CDC42 (PubMed:15157669). ; [Isoform 3]: Does not catalyze guanine nucleotide exchange on CDC42 (PubMed:15157669).

Matrix Type

Tissue/Cells

Gene Symbol

MCF2L

UniProt ID

O15068
O15068-2
O15068-3
O15068-4
O15068-5
O15068-6
O15068-8
O15068-9

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MCF2L

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Matrix Type

Gene Symbol

UniProt ID

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