KCNN4

Intermediate conductance calcium-activated potassium channel protein 4

Forms a voltage-independent potassium channel that is activated by intracellular calcium (PubMed:26148990). Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells (PubMed:17157250, PubMed:18796614). Plays a role in the late stages of EGF-induced macropinocytosis (PubMed:24591580).

Associated with:

Matrix Type

  • Tissue/Cells

Gene Symbol

  • KCNN4

UniProt ID

  • O15554

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