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I2BP2

Interferon regulatory factor 2-binding protein 2; Isoform 2 of Interferon regulatory factor 2-binding protein 2;Isoform 2 of Interferon regulatory factor 2-binding protein 2

Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities (PubMed:12799427). Represses the NFAT1-dependent transactivation of NFAT-responsive promoters (PubMed:21576369). Acts as a coactivator of VEGFA expression in cardiac and skeletal muscles (PubMed:20702774). Plays a role in immature B-cell differentiation (PubMed:27016798).

    Matrix Type

    • Tissue/Cells

    Gene Symbol

    • IRF2BP2

    UniProt ID

    • Q7Z5L9
    • Q7Z5L9-2
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