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ILRUN

Protein ILRUN

Negative regulator of innate antiviral response. Blocks IRF3-dependent cytokine production such as IFNA, IFNB and TNF (PubMed:29802199). Interacts with IRF3 and inhibits IRF3 recruitment to type I IFN promoter sequences while also reducing nuclear levels of the coactivators EP300 and CREBBP (PubMed:29802199).

Associated with:

Matrix Type

  • Tissue/Cells

Gene Symbol

  • ILRUN

UniProt ID

  • Q9H6K1
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