HPS4

Isoform 4 of BLOC-3 complex member HPS4; Isoform 2 of BLOC-3 complex member HPS4;BLOC-3 complex member HPS4; Isoform 3 of BLOC-3 complex member HPS4

Component of the BLOC-3 complex, a complex that acts as a guanine exchange factor (GEF) for RAB32 and RAB38, promotes the exchange of GDP to GTP, converting them from an inactive GDP-bound form into an active GTP-bound form. The BLOC-3 complex plays an important role in the control of melanin production and melanosome biogenesis and promotes the membrane localization of RAB32 and RAB38 (PubMed:23084991).

Associated with:

Matrix Type

  • Tissue/Cells

Gene Symbol

  • HPS4

UniProt ID

  • Q9NQG7
  • Q9NQG7-3
  • Q9NQG7-4

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