Orphan receptor. Could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways. Functions as a negative modulator of EGFR signaling (By similarity). May act as a lung tumor suppressor (PubMed:18000218).

Associated with:

Matrix Type

  • Tissue/Cells

Gene Symbol

  • GPRC5A

UniProt ID

  • Q8NFJ5

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