ERBB3

Isoform 4 of Receptor tyrosine-protein kinase erbB-3;Receptor tyrosine-protein kinase erbB-3

Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134). Involved in the regulation of myeloid cell differentiation (PubMed:27416908).

Matrix Type

  • Tissue/Cells

Gene Symbol

  • ERBB3

UniProt ID

  • P21860

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