EDEM2

Isoform 2 of ER degradation-enhancing alpha-mannosidase-like protein 2;ER degradation-enhancing alpha-mannosidase-like protein 2

Involved in the endoplasmic reticulum-associated degradation (ERAD) pathway that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner (PubMed:15537790, PubMed:25092655). May initiate ERAD by promoting the first mannose trimming step of ERAD substrates, from Man9GlcNAc2 to Man8GlcNAc2 (PubMed:25092655). Seems to recognize and bind to exposed hydrophobic regions in target proteins (By similarity).

    Matrix Type

    • Tissue/Cells

    Gene Symbol

    • EDEM2

    UniProt ID

    • Q9BV94

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