DVL1

Segment polarity protein dishevelled homolog DVL-1; Isoform 2 of Segment polarity protein dishevelled homolog DVL-1

Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ).

Matrix Type

  • Tissue/Cells

Gene Symbol

  • DVL1

UniProt ID

  • O14640

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