Functions as a guanine nucleotide exchange factor (GEF) that promotes the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form (PubMed:12628187, PubMed:16464467). Involved in regulation of adherens junction between cells (PubMed:12628187). Plays a role in cell migration (PubMed:20679435). ; [Isoform 2]: Has a higher guanine nucleotide exchange factor activity compared to other isoforms.

Matrix Type

  • Tissue/Cells

Gene Symbol

  • DOCK4

UniProt ID

  • Q8N1I0

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