DGKH

Diacylglycerol kinase eta;Diacylglycerol kinase eta; Isoform 3 of Diacylglycerol kinase eta; Isoform 4 of Diacylglycerol kinase eta; Isoform 2 of Diacylglycerol kinase eta

Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:12810723, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable) (PubMed:12810723, PubMed:23949095). Plays a key role in promoting cell growth (PubMed:19710016). Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF (PubMed:19710016). Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization (PubMed:19710016).

Matrix Type

  • Plasma
  • Tissue/Cells

Gene Symbol

  • DGKH

UniProt ID

  • Q86XP1
  • Q86XP1-3
  • Q86XP1-5

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