DCST1

E3 ubiquitin-protein ligase DCST1; Isoform 3 of E3 ubiquitin-protein ligase DCST1; Isoform 2 of E3 ubiquitin-protein ligase DCST1

E3 ubiquitin-protein ligase which mediates ‘Lys-48’-linked ubiquitination of STAT2 and induces its proteasomal degradation thereby negatively regulating type-I-interferon signaling. Essential sperm cell-surface protein required for sperm-egg fusion and fertilization (By similarity).

Matrix Type

  • Tissue/Cells

Gene Symbol

  • DCST1

UniProt ID

  • Q5T197
  • Q5T197-3

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