DAAM1

Isoform 3 of Disheveled-associated activator of morphogenesis 1;Disheveled-associated activator of morphogenesis 1; Isoform 2 of Disheveled-associated activator of morphogenesis 1;Disheveled-associated activator of morphogenesis 1

Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments. Involved in building functional cilia (PubMed:16630611, PubMed:17482208). Involved in the organization of the subapical actin network in multiciliated epithelial cells (By similarity). Together with DAAM2, required for myocardial maturation and sarcomere assembly (By similarity).

Matrix Type

  • Plasma
  • Tissue/Cells

Gene Symbol

  • DAAM1

UniProt ID

  • Q9Y4D1
  • Q9Y4D1-3

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