CTNA2

Catenin alpha-2; Isoform 2 of Catenin alpha-2; Isoform 5 of Catenin alpha-2

May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system (By similarity). Required for proper regulation of cortical neuronal migration and neurite growth (PubMed:30013181). It acts as a negative regulator of Arp2/3 complex activity and Arp2/3-mediated actin polymerization (PubMed:30013181). It thereby suppresses excessive actin branching which would impair neurite growth and stability (PubMed:30013181). Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation (By similarity).

Matrix Type

  • Tissue/Cells

Gene Symbol

  • CTNNA2

UniProt ID

  • P26232
  • P26232-5

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