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CKLF4

Isoform 2 of CKLF-like MARVEL transmembrane domain-containing protein 4; Isoform 3 of CKLF-like MARVEL transmembrane domain-containing protein 4;CKLF-like MARVEL transmembrane domain-containing protein 4

Acts as a backup for CMTM6 to regulate plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. May protect PD-L1/CD274 from being polyubiquitinated and targeted for degradation.

    Matrix Type

    • Tissue/Cells

    Gene Symbol

    • CMTM4

    UniProt ID

    • Q8IZR5
    • Q8IZR5-3
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