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BBC3

Bcl-2-binding component 3, isoforms 1/2

Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis (PubMed:11463391, PubMed:23340338). Promotes partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53, releasing the bound p53/TP53 to induce apoptosis (PubMed:23340338). Regulates ER stress-induced neuronal apoptosis (By similarity).

    Matrix Type

    • Tissue/Cells

    Gene Symbol

    • BBC3

    UniProt ID

    • Q9BXH1
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