ASZ1

Isoform 2 of Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1;Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1

Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation (By similarity).

    Matrix Type

    • Tissue/Cells

    Gene Symbol

    • ASZ1

    UniProt ID

    • Q8WWH4

    Request the ASZ1 Assay

    Tell us a little more about your study so we can optimize the assay for your specific needs.

    "*" indicates required fields

    This field is for validation purposes and should be left unchanged.