ATS4

A disintegrin and metalloproteinase with thrombospondin motifs 4; Isoform 2 of A disintegrin and metalloproteinase with thrombospondin motifs 4

Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the ‘392-Glu-; -Ala-393’ site.

Associated with:

Acute Renal Failure
Alanine Transaminase
Albumin
Alkaline Phosphatase
Apolipoprotein A
Apolipoprotein B
Aspartate Transaminase
Asthma
Basal Metabolic Rate
Basophils
BMI
Breast Cancer
C Reactive Protein
Calcium
Calcium Albumin Ratio
Cancer
Chronic Lymphocytic Leukemia And Small Lymphocytic Lymphoma
Chronic Nephritic Syndrome
Chronic Obstructive Pulmonary Disease
Chronic Renal Failure
Chronik Kidney Diesase
Creatinine
Cystatin C
Diastolic Blood Pressure
Direct Bilirubin
Eosinophils
Erythrocyte Sedimentation Rate
Estimated Glomerular Filtration Rate
Folate
FT3 FT4 Ratio
Gamma Glutamyltransferase
Glomerular Disorders
Glucose
Gout
Granulocytes
HbA1c
Heart Failure
Heartrate
Height
Hematocrit
Hemoglobin
High Density Lipoprotein Cholesterol
Hypertension
IgA
IGF1
Iron
Kidney Failure
Lactate Dehydrogenase
Leukocytes
Low Density Lipoprotein Cholesterol
Lung Cancer
Lymphocytes
Metabolic Syndrome
Monocytes
Neutrophils
Peripheral Vascular Disease
Phosphate
Physical Activity
Platelet
Pneumonia
Potassium
Red Blood Cell Count
Renal Failure
Reticulocytes
Septicaemia
Severe Obesity (BMI > 35)
Sleep Apnea
Systemic Lupus
Systolic Blood Pressure
Testosterone
Thyroid FT3
Total Bilirubin
Total Cholesterol
Total Fat
Total Lean Muscle
Transferrin Saturation
Triglyceride
Type 2 Diabetes
Urea
Uric Acid
Urine Glucose
Urine Protein
Vitamin D
Waist Circumference
Waist Hip Ratio
Weight
White Blood Cell
Whole Body Fat
Extracellular Matrix Organization

Matrix Type

Tissue/Cells

Gene Symbol

ADAMTS4

UniProt ID

O75173

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ATS4

A disintegrin and metalloproteinase with thrombospondin motifs 4; Isoform 2 of A disintegrin and metalloproteinase with thrombospondin motifs 4

Associated with:

Matrix Type

Gene Symbol

UniProt ID

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