Identifying Non-Invasive Biomarkers of Target Engagement

A key aspect of the drug discovery pipeline is evaluation of in vivo target engagement and subsequent biological response. While measures of target engagement are often optimized in cellular and preclinical systems, direct measures of tissue target engagement are often limited in human subjects as part of early clinical studies. Metabolites in blood may serve as a robust, non-invasive biomarkers of target engagement, providing measurements to better evaluate tissue penetration, target engagement, and therapeutic response, and ultimately guide drug dosing.