[Protein SLFN14]: Shows no ribosome-associated and endoribonuclease activities. {ECO:0000269|PubMed:25996083}.; [C-terminally truncated SLFN14 endoribonuclease]: Displays polysome-associated endoribonuclease activity towards mRNAs and rRNAs (PubMed:25996083). May play a role in RNA surveillance pathways by recognizing stalled ribosomes and triggering endonucleolytic cleavage of aberrant mRNAs (Probable). Cleaves different types of rRNAs and mRNAs in a magnesium- and manganese-dependent and ATP-independent manner (By similarity). Involved in correct maturation of megakaryocytes and especially important for proplatelet extension. {ECO:0000250|UniProtKB:G1SRW8, ECO:0000269|PubMed:25996083, ECO:0000269|PubMed:26769223, ECO:0000305|PubMed:25996083}.

    Matrix Type

    • Plasma
    • Tissue/Cells

    Gene Symbol

    • SLFN14

    UniProt ID

    • P0C7P3

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