Isoform 2 of Sodium channel protein type 1 subunit alpha; Isoform 3 of Sodium channel protein type 1 subunit alpha;Sodium channel protein type 1 subunit alpha

Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (PubMed:14672992). Plays a key role in brain, probably by regulating the moment when neurotransmitters are released in neurons. Involved in sensory perception of mechanical pain: activation in somatosensory neurons induces pain without neurogenic inflammation and produces hypersensitivity to mechanical, but not thermal stimuli. {ECO:0000250|UniProtKB:A2APX8, ECO:0000269|PubMed:14672992}.

    Matrix Type

    • Tissue/Cells

    Gene Symbol

    • SCN1A

    UniProt ID

    • P35498
    • P35498-3

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